The relationship between cardio and muscle growth is much more complex than people make it out to be. Aerobic exercise provides many beneficial effects on the cardiovascular system that cannot be achieved through resistance exercise; however, there are appropriate times to perform cardio that will not interfere with muscle gains.



  • Recent research lays doubt that cardio burns muscle as commonly suggested.
  • Training with cardio and resistance exercise in excess can cause blunted muscle growth.
  • The greater the frequency, intensity, and duration of cardio, the greater its impact on reducing muscle growth.
  • The interference effect seems more prominent with running, whereas cycling has less impact.
  •  The benefits of adding cardio to resistance exercise are improving cardiovascular function and muscle blood flow.
  •  Cardio can enhance recovery by increasing blood flow to muscles and improving cardiovascular health.


Training with aerobic and resistance exercises has sometimes been shown to produce less than favorable increases in muscle growth. This blunted effect on muscle growth is known as the interference effect.

There have been conflicting studies on the interference effect. Some studies show a blunted effect on muscle growth, whereas others have found no effect of combined cardio and resistance exercise.


A recent meta-analysis examined 15 studies with more than 300 subjects, the duration and type of cardio, and the outcomes on muscle growth of type I and II fibers.

After the researchers performed the analysis, they found a small reduction in muscle hypertrophy when aerobic exercise was combined with resistance exercise. The reductions in muscle size were found in type I fibers, which were affected the most.

The researchers suspected that since aerobic exercise mainly affects type I fibers, the combined effect of cardio and resistance exercise can cause negative adaptations in these muscle fibers.

Interestingly, they only found reductions in muscle size when running was combined with resistance exercise, whereas no effect was found with cycling. Running is associated with repetitive eccentric loading and stretch-shortening activities, whereas cycling provokes a higher emphasis on concentric work and a longer time under tension.

This may, in turn, be associated with greater inflammatory stress induced by running than cycling, possibly increasing redox and metabolic stress that may blunt the responsiveness to strength exercise.

None of the other subgroup analyses (i.e., based on concurrent training frequency, training status, training modality, and training order of same-session training) revealed a statistically significant interference effect for fiber hypertrophy.(12) To minimize the effect of the interference effect, here are some suggestions:

·      Perform cardio and resistance exercises spaced at least 6 hours apart. Preferably cardio in the morning and resistance exercise in the afternoon.

·      If you have to perform both, perform resistance exercise first, followed by cardio.


  •        The data indicate that strength training before aerobic exercise, but not aerobic exercise before strength training, is more effective for improving muscle strength.
  •        Aerobic exercise resulted in acute moderate declines in measures of muscle strength but not power in trained male individuals.
  •        There was a negative influence of prior moderate-to-high intensity and longer aerobic exercise durations (i.e., > 30 min) on muscle strength in trained male individuals. Low-intensity and short-duration (i.e., ≤ 30 min) aerobic exercise appear not to compromise strength performance.
  •        Compared with running exercise, cycling causes larger decrements in lower limb muscle strength. (11)


 When the first publication on concurrent training was released, people went crazy and perceived that aerobic exercise blunted muscle growth. First, the studies regarding concurrent training should be placed in context.

The studies that showed a blunted effect on muscle growth did excessive aerobic exercise (i.e., 40 minutes of aerobic exercise six days a week) combined with a 40-minute weight training program. (13)

Previous research suggests that the interference effect depends on several factors, such as training frequency, duration, and exercise intensity. (14) A 2021 meta-analysis compared the interference effect, which comprised over 43 studies with over 1,090 participants. The meta-analysis examined explosive strength, maximal strength, and muscle growth.

The study results concluded that concurrent training did not interfere with muscle growth or strength gains compared to strength training alone. However, they found that explosive strength was reduced with concurrent training, likely because of excessive fatigue.

The researchers found that separating resistance from aerobic exercise by 3 hours resulted in no reductions in explosive strength.(15) Don’t perform explosive exercise immediately after resistance and aerobic exercise. It is best to wait greater than 3 hours to perform an explosive exercise.


Lifters frequently use cardio to promote fat loss and build lean muscle. Recent studies indicate that when lifters do cardio right after resistance exercise, it might reduce the muscle growth effect. This observation has led many lifters to consider avoiding cardio when their goal is muscle building. However, the link between cardio and muscle growth is more nuanced than many assume. While aerobic workouts benefit the cardiovascular system in ways resistance exercises can’t, there are ideal times to incorporate cardio that won’t compromise muscle development.

There has been a ton of research on the interference effect. Research has shown that performing excessive cardio and weight training together can impair muscle growth. Cardio won’t completely stop muscle growth gains, but it can slow down the process.

Most research has been done on the leg muscles showing lower muscle growth when cardio and resistance exercise are combined. Some have speculated that it disrupts anabolic signaling pathways, glycogen depletion, excessive fatigue, etc.[1] Training with excessive aerobic exercise and resistance exercise stimulates fewer anabolic signaling pathways.


Cardio can take valuable resources (i.e., calories) away from muscle growth. The factors that determine whether combing cardio and resistance exercise together blunt muscle growth is the type of cardio you do, the volume and intensity of the cardio performed, and whether you do cardio in a close period with weight training.

High-intensity cardio after resistance exercise was found to result in less muscle growth (1.8%), whereas moderate-intensity exercise had a lesser effect (3.6%) compared to resistance exercise performed alone (4.1%).[2] One meta-analysis found that the greater the frequency and duration of cardio, the greater its impact on reducing muscle growth.[3]

Studies on Does Cardio Burn Muscle

A 2021 meta-analysis found that concurrent training is more adverse for trained individuals than untrained ones, but spacing your cardio apart from resistance exercise by three hours seemed to block the interference effect from reducing strength gains in trained athletes.[4]

Most studies looking at the interference effect have used running and weightlifting; however, a recent meta-analysis found no impact of cycling and weightlifting on muscle growth.[5] Researchers suspect that since running involves high eccentric contractions, like excessive eccentric training, this can cause excess muscle damage.

Cycling does not have high eccentric contractions, hence less muscle damage. However, a recent study found that high-intensity cycling directly after resistance exercise can cause an interference effect for strength gains but not muscle hypertrophy. Researchers divided women into two groups. One group performed only resistance exercise for six weeks. The other group completed the resistance exercise and did high-intensity interval cycling 10 minutes after each lifting session. The cycling protocol consisted of 10 × 1-minute intervals at maximum aerobic power, with the workload being increased by 5% each week.

There was 1-minute of passive rest between each interval. If you can imagine doing 10 one-minute maximal sprint sessions after a workout, you know how this study ended. The resistance-only training session increased power tests such as the countermovement jump, but the combined high intensity and cycling group did not. However, despite the differences in power production between the two groups, there was no difference in muscle size or strength between the two groups.[6]

Studies on Does Cardio Burn Muscle

If you must do cardio, make sure it is after resistance exercise. Researchers found that 1-RM was significantly less when resistance exercise was done before cardio in a meta-analysis.[7] If you perform cardio first, you can deplete valuable glycogen, which will lead to reduced subsequent resistance exercise performance and volume. Reduced glycogen stores have been found to negatively affect anabolic signaling pathways.[8]

Combining both activities in a single session leads to greater glycogen depletion, increased sympathetic nervous activity, and increased stress hormones, impairing the recovery process.

Keep in mind that excessive cardio will result in a greater caloric deficit, and as you know, it’s tough to gain muscle when you are in a caloric deficit. A recent meta-analysis found that an energy deficit impairs building muscle mass.

They also found that an energy deficit of 500 calories per day prevented building lean mass in response to resistance training in a state of normal energy balance.[9] Most experts believe a caloric surplus of 300-500 calories per day can enhance lean muscle mass while minimizing unnecessary gains in fat. It is much easier to gain muscle if you eat a caloric surplus.


  • Recent research suggests that cardio does not burn muscle when adequate calories are consumed.


1.     Jackson J. Fyfe, David J. Bishop, and Nigel K. Stepto, “Interference between Concurrent Resistance and Endurance Exercise: Molecular Bases and the Role of Individual Training Variables,” Sports Medicine (Auckland, N.Z.) 44, no. 6 (June 2014): 743–62.

2.     Jackson J. Fyfe et al., “Endurance Training Intensity Does Not Mediate Interference to Maximal Lower-Body Strength Gain during Short-Term Concurrent Training,” Frontiers in Physiology 7 (November 3, 2016): 487.

3.     Kevin A. Murach and James R. Bagley, “Skeletal Muscle Hypertrophy with Concurrent Exercise Training: Contrary Evidence for an Interference Effect,” Sports Medicine 46, no. 8 (August 2016): 1029–39.

4.     Henrik Petré et al., “Development of Maximal Dynamic Strength During Concurrent Resistance and Endurance Training in Untrained, Moderately Trained, and Trained Individuals: A Systematic Review and Meta-Analysis,” Sports Medicine (Auckland, N.Z.) 51, no. 5 (May 2021): 991–1010.

5.     Jacob M. Wilson et al., “Concurrent Training: A Meta-Analysis Examining Interference of Aerobic and Resistance Exercises,” Journal of Strength and Conditioning Research 26, no. 8 (August 2012): 2293–2307.

6.     Polyxeni Spiliopoulou et al., “Effect of Concurrent Power Training and High-Intensity Interval Cycling on Muscle Morphology and Performance,” Journal of Strength and Conditioning Research 35, no. 9 (September 1, 2021): 2464–71.

7.     Zsolt Murlasits, Zsuzsanna Kneffel, and Lukman Thalib, “The Physiological Effects of Concurrent Strength and Endurance Training Sequence: A Systematic Review and Meta-Analysis,” Journal of Sports Sciences 36, no. 11 (June 2018): 1212–19.


8.     Andrew Creer et al., “Influence of Muscle Glycogen Availability on ERK1/2 and Akt Signaling after Resistance Exercise in Human Skeletal Muscle,” Journal of Applied Physiology 99, no. 3 (September 1, 2005): 950–56.

9.     Chaise Murphy and Karsten Koehler, “Energy Deficiency Impairs Resistance Training Gains in Lean Mass but Not Strength: A Meta-Analysis and Meta-Regression,” Scandinavian Journal of Medicine & Science in Sports, October 8, 2021.

10.  Natalie R. Janzen, Jamie Whitfield, and Nolan J. Hoffman, “Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism,” International Journal of Molecular Sciences 19, no. 11 (October 26, 2018): 3344.

11. Markov, A., Chaabene, H., Hauser, L. et al. Acute Effects of Aerobic Exercise on Muscle Strength and Power in Trained Male Individuals: A Systematic Review with Meta-analysis. Sports Med (2021).

12. Lundberg TR, Feuerbacher JF, Sünkeler M, Schumann M. The Effects of Concurrent Aerobic and Strength Training on Muscle Fiber Hypertrophy: A Systematic Review and Meta-Analysis. Sports Med. 2022.

13. Hickson RC. Interference of strength development by simultaneously training for strength and endurance. Eur J Appl Physiol Occup Physiol. 1980;45(2-3):255-63.

14. Wilson JM, Marin PJ, Rhea MR, Wilson SM, Loenneke JP, Anderson JC. Concurrent training: a meta-analysis examining interference of aerobic and resistance exercises. J Strength Cond Res. 2012;26(8):2293-307.


15. Schumann M, Feuerbacher JF, Sünkeler M, Freitag N, Rønnestad BR, Doma K, et al. Compatibility of Concurrent Aerobic and Strength Training for Skeletal Muscle Size and Function: An Updated Systematic Review and Meta-Analysis. Sports Medicine. 2022;52(3):601-12.

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